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KMID : 0941819960060020001
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Korean Journal of Clinical Pharmacy
1996 Volume.6 No. 2 p.1 ~ p.6
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Chronopharmacokinetics of Vancomycin in Normal Volunteers
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최준식
유재신/최병철/김진/범진필/최경업
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Abstract
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Carcadian rhythm dependence of vancomycin pharmacokinetics was evaluated in 5 normal volunteers receiving a single intravenous 1.0 g dose of vancomycin at 8 o’’clock in the morning and another occasion at 8 o’’clock in the evening in a crossover manner. The serum data were subjected to simultaneous computer nonlinear least squares regression analysis using a two-compartment pbarmacokinetic model. The mean half-life of vancomycin was 4.78pm0.81 hr in the morning and 4.25pm0.51 hr in the evening. The mean total body clearance of vancomycin was 1.29pm0.58 hr in the morning and 5.58pm0.48 hr in the evening. No circadian rhythm was found to be apparent in normal volunteers. The mean in intrasubject difference in the half-life between 8 A.M. and 8 P.M. was 15.4% with fluctuations ranging from 10.4sim33.8%, It is reasonable to consider individual circadian rhythm for effective dosage regimen of vancomycin in clinical chronotherapeutics.
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